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Pyridoxine/doxylamine. Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride ( vitamin B 6) and doxylamine succinate. It is generally used for nausea and vomiting of pregnancy (morning sickness); even though its efficacy has not been proven and subsequent research has led to the ...
Thalidomide was introduced in 1953 as a tranquilizer, and was later marketed by the German pharmaceutical company Chemie Grünenthal under the trade name Contergan as a medication for anxiety, trouble sleeping, tension, and morning sickness. [3] [4] It was introduced as a sedative and medication for morning sickness without having been tested on pregnant women. [5] While initially deemed to be ...
Thalidomide is a known human teratogen and carries an extremely high risk of severe, life-threatening birth defects if administered during pregnancy. It causes skeletal deformities such as amelia (absence of legs and/or arms), absence of bones, and phocomelia (malformation of the limbs).
Expecting women know to anticipate morning sickness, a potentially debilitating side effect that plagues 80% of pregnant women. But scientists haven’t been sure as to why the misery occurs ...
The drug was used between 1957-62 as a sedative and to treat morning sickness in early pregnancy. A serious side effect, however, resulted in over 10,000 children being born with severe birth defects.
During pregnancy, anyone experiencing morning sickness is often prescribed a combination tablet of doxylamine - an antihistamine - and vitamin B6.
Doxylamine, sold under the brand name Unisom among others, is an antihistamine medication which is used in the treatment of insomnia and allergies. It is also used to treat morning sickness in pregnant women in combination with pyridoxine ( vitamin B 6 ). Doxylamine is available over-the-counter, and is used in nighttime cold medicines, such as ...
Phocomelia is a congenital condition that involves malformations of human arms and legs which results in a flipper-like appendage. [1] [2] A prominent cause of phocomelia is the mother's use of the drug thalidomide during pregnancy; however, the causes of most cases are to be determined. [2]