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Polychlorinated dibenzo -p- dioxins (PCDDs), or simply dioxins. PCDDs are derivatives of dibenzo -p- dioxin. There are 75 PCDD congeners, differing in the number and location of chlorine atoms, and 7 of them are specifically toxic, the most toxic being 2,3,7,8-tetrachlorodibenzodioxin (TCDD). Polychlorinated dibenzofurans (PCDFs), or furans.
2,3,7,8-Tetrachlorodibenzodioxin (TCDD) is considered the most toxic of the congeners (for the mechanism of action, see 2,3,7,8-Tetrachlorodibenzodioxin and Aryl hydrocarbon receptor). Other dioxin congeners including PCDFs and PCBs with dioxin-like toxicity, are given a toxicity rating from 0 to 1, where TCDD = 1 (see Dioxins and dioxin-like ...
Infobox references. 2,3,7,8-Tetrachlorodibenzo-p-dioxin ( TCDD) is a polychlorinated dibenzo -p- dioxin (sometimes shortened, though inaccurately, to simply 'dioxin') [ 3] with the chemical formula C 12 H 4 Cl 4 O 2. Pure TCDD is a colorless solid with no distinguishable odor at room temperature.
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It is a polycyclic heterocyclic organic compound, since HpCDD contains multiple cyclic structures (two benzene rings connected by a 1,4-dioxin ring) in which two different elements (carbon and oxygen) are members of its rings. [1] HpCDD has molecular formula C 12 HCl 7 O 2 and is an off-white powder, which is insoluble in water.
Toxic equivalency factor ( TEF) expresses the toxicity of dioxins, furans and PCBs in terms of the most toxic form of dioxin, 2,3,7,8-TCDD. [ 1] The toxicity of the individual congeners may vary by orders of magnitude . With the TEFs, the toxicity of a mixture of dioxins and dioxin-like compounds can be expressed in a single number – the ...
It resulted in the highest known exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in residential populations, [1] which gave rise to numerous scientific studies and standardized industrial safety regulations, including the European Union's Seveso III Directive.