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Sirtuin. Sirtuins are a family of signaling proteins involved in metabolic regulation. [ 2][ 3] They are ancient in animal evolution and appear to possess a highly conserved structure throughout all kingdoms of life. [ 2] Chemically, sirtuins are a class of proteins that possess either mono- ADP-ribosyltransferase or deacylase activity ...
Sirtuin-activating compound. Sirtuin-activating compounds ( STAC) are chemical compounds having an effect on sirtuins, a group of enzymes that use NAD+ to remove acetyl groups from proteins. They are caloric restriction mimetic compounds that may be helpful in treating various aging -related diseases. [ 1]
Sirtuin 6. Sirtuin 6 ( SIRT6 or Sirt6) is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. [ 5][ 6][ 7] In laboratory research, SIRT6 appears to function in multiple molecular pathways related to aging, including DNA repair, telomere maintenance, glycolysis and inflammation. [ 5]
Sirtuin 3. NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)]. [ 5][ 6] SIRT3 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein.
51547 209011 Ensembl ENSG00000187531 ENSMUSG00000025138 UniProt Q9NRC8 Q8BKJ9 RefSeq (mRNA) NM_016538 NM_153056 NM_001363439 RefSeq (protein) NP_057622 NP_694696 NP_001350368 Location (UCSC) Chr 17: 81.91 – 81.92 Mb Chr 11: 120.51 – 120.52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse NAD-dependent deacetylase sirtuin 7 is an enzyme that in humans is encoded by the SIRT7 gene ...
Sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae), also known as SIRT5 is a protein which in humans in encoded by the SIRT5 gene and in other species by the orthologous Sirt5 gene. [5] This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein.
The dog even shook her head when the girl was finished. "She said no!" she exclaimed to her mom as she turned. "She shaked her head no like this," the little girl added. People in the comments ...
Sirtuin 2. NAD-dependent deacetylase sirtuin 2 is an enzyme that in humans is encoded by the SIRT2 gene. [5] [6] [7] SIRT2 is an NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase. Studies of this protein have often been divergent, highlighting the dependence of pleiotropic effects of SIRT2 on cellular context.
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