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Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride (vitamin B 6) and doxylamine succinate.It is generally used for nausea and vomiting of pregnancy (morning sickness); even though its efficacy has not been proven and subsequent research has led to the removal of recommendations in medical journals.
Feet of a baby born to a mother who had taken thalidomide while pregnant. In the late 1950s and early 1960s, the use of thalidomide in 46 countries by women who were pregnant or who subsequently became pregnant resulted in the "biggest anthropogenic medical disaster ever," with more than 10,000 children born with a range of severe deformities, such as phocomelia, as well as thousands of ...
Thalidomide, sold under the brand names Contergan and Thalomid among others, is an oral medication used to treat a number of cancers ( e.g., multiple myeloma ), graft-versus-host disease, and many skin disorders ( e.g., complications of leprosy such as skin lesions ). [ 6][ 7][ 8] Thalidomide has been used to treat conditions associated with ...
The drug was used between 1957-62 as a sedative and to treat morning sickness in early pregnancy. A serious side effect, however, resulted in over 10,000 children being born with severe birth defects.
As an antihistamine, doxylamine is an inverse agonist of the histamine H 1 receptor. As a first-generation antihistamine, it typically crosses the blood–brain barrier into the brain, thereby producing a suite of sedative and hypnotic effects that are mediated by the central nervous system. (N.b.:
Phocomelia is a congenital condition that involves malformations of human arms and legs which results in a flipper-like appendage. [ 1][ 2] A prominent cause of phocomelia is the mother's use of the drug thalidomide during pregnancy; however, the causes of most cases are to be determined. [ 2]
Vitamin B 6 is a water-soluble vitamin, one of the B vitamins. The vitamin actually comprises a group of six chemically related compounds, i.e., vitamers, that all contain a pyridine ring as their core. These are pyridoxine, pyridoxal, pyridoxamine, and their respective phosphorylated derivatives pyridoxine 5'-phosphate, pyridoxal 5'-phosphate ...
Enantiopure drug. An enantiopure drug is a pharmaceutical that is available in one specific enantiomeric form. Most biological molecules (proteins, sugars, etc.) are present in only one of many chiral forms, so different enantiomers of a chiral drug molecule bind differently (or not at all) to target receptors.
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related to: how to take b6 and unisom for morning sickness pills birth defects meaning