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Scanning electron micrograph of HIV-1, colored green, budding from a cultured lymphocyte. HIV is the cause of the spectrum of disease known as HIV/AIDS. HIV is a retrovirus that primarily infects components of the human immune system such as CD4 + T cells, macrophages and dendritic cells. It directly and indirectly destroys CD4 + T cells.
Visna-maedi virus. The human immunodeficiency viruses ( HIV) are two species of Lentivirus (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), [1] [2] a condition in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. [3]
The evidence that HIV causes AIDS is generally considered conclusive among pathologists. Most arguments for denialism are based on misrepresentations of outdated data. [125] [126] The belief that HIV was created by the US government as a bioweapon , an idea invented by a Soviet propaganda operation , [127] [128] is held by a disproportionately ...
See also: Timeline of early HIV/AIDS cases. Researchers estimate that some time in the early 20th century, a form of Simian immunodeficiency virus found in chimpanzees (SIVcpz) first entered humans in Central Africa and began circulating in LĂ©opoldville (modern-day Kinshasa) by the 1920s. [1] [2] [3] This gave rise to the pandemic form of HIV ...
The AIDS epidemic, caused by HIV (Human Immunodeficiency Virus), found its way to the United States between the 1970s and 1980s, [2] but was first noticed after doctors discovered clusters of Kaposi's sarcoma and pneumocystis pneumonia in homosexual men in Los Angeles, New York City, and San Francisco in 1981.
Pathophysiology of HIV/AIDS. HIV is commonly transmitted via unprotected sexual activity, blood transfusions, hypodermic needles, and from mother to child. Upon acquisition of the virus, the virus replicates inside and kills T helper cells, which are required for almost all adaptive immune responses. There is an initial period of influenza-like ...
The global pandemic of HIV/AIDS (human immunodeficiency virus infection and acquired immunodeficiency syndrome) began in 1981, and is an ongoing worldwide public health issue. [4] [5] [6] According to the World Health Organization (WHO), by 2023, HIV/AIDS had killed approximately 40.4 million people, and approximately 39 million people were ...
In 1998, AIDS was the fifth leading cause of death among women aged 25 to 44 in the United States, and the third leading cause of death among African-American women in that age group. [81] In Africa, HIV was first recognized in sexually active heterosexuals , and AIDS cases in Africa have occurred at least as frequently in women as in men.