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2. Sirtuin - Wikipedia

   en.wikipedia.org/wiki/Sirtuin

   Sirtuin. Sirtuins are a family of signaling proteins involved in metabolic regulation. [ 2][ 3] They are ancient in animal evolution and appear to possess a highly conserved structure throughout all kingdoms of life. [ 2] Chemically, sirtuins are a class of proteins that possess either mono- ADP-ribosyltransferase or deacylase activity ...

3. This Land Is My Land - Wikipedia

   en.wikipedia.org/wiki/This_Land_Is_My_Land

   Release. October 20, 2021. Genre (s) Stealth, action. Mode (s) Single-player. This Land is My Land is a stealth action video game developed and published by Game-Labs. It was released in early access for Windows in 2019, prior to its full release in October 2021. The game is set in the 19th-century American frontier and features a Native ...

4. Leonard P. Guarente - Wikipedia

   en.wikipedia.org/wiki/Leonard_P._Guarente

   That same year, David Sinclair joined the Guarente lab, and they developed the hypothesis that caloric restriction slows aging by activation of sirtuins. [8] The Kenyon and Guarente labs came to lead the field studying the genetics of aging. [9] In 1995 the Guarente lab identified the gene SIR4 (Silent information regulator 4) as a longevity ...

5. Sirtuin 6 - Wikipedia

   en.wikipedia.org/wiki/Sirtuin_6

   Sirtuin 6. Sirtuin 6 ( SIRT6 or Sirt6) is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. [ 5][ 6][ 7] In laboratory research, SIRT6 appears to function in multiple molecular pathways related to aging, including DNA repair, telomere maintenance, glycolysis and inflammation. [ 5]

6. Sirtuin-activating compound - Wikipedia

   en.wikipedia.org/wiki/Sirtuin-activating_compound

   Sirtuin-activating compound. Sirtuin-activating compounds ( STAC) are chemical compounds having an effect on sirtuins, a group of enzymes that use NAD+ to remove acetyl groups from proteins. They are caloric restriction mimetic compounds that may be helpful in treating various aging -related diseases. [ 1]

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9. Sirtuin 3 - Wikipedia

   en.wikipedia.org/wiki/Sirtuin_3

   Sirtuin 3. NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)]. [ 5][ 6] SIRT3 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein.