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In this trial (the NICE-SUGAR Study), patients randomised to the intensive glucose control group had a target blood sugar range of 4.5 to 6.0 mmol/L while those placed in the conventional glucose control group had a blood glucose target range of 8.0 to 10.0 mmol/L (as compared to 10.0 to 11.1 mmol/L in Van den Berghe, 2001).
The reference ranges for the complete blood count represent the range of results found in 95% of apparently healthy people. [note 2] [35] By definition, 5% of results will always fall outside this range, so some abnormal results may reflect natural variation rather than signifying a medical issue. [36]
Impaired fasting glucose is a type of prediabetes, in which a person's blood sugar levels during fasting are consistently above the normal range, but below the diagnostic cut-off for a formal diagnosis of diabetes mellitus. [2] Together with impaired glucose tolerance, it is a sign of insulin resistance.
Hyperchloremia is an electrolyte disturbance in which there is an elevated level of chloride ions in the blood. [1] The normal serum range for chloride is 96 to 106 mEq/L, [2] therefore chloride levels at or above 110 mEq/L usually indicate kidney dysfunction as it is a regulator of chloride concentration. [3]
Once blood glucose levels fall out of the normal range, additional protective mechanisms work to prevent hypoglycemia. [3] [16] The pancreas is signaled to release glucagon, a hormone that increases glucose production by the liver and kidneys, and increases muscle and fat breakdown to supply gluconeogenesis.
A dysplasia is a disorder at the organ level that is due to problems with tissue development. [16] Conditions also can arise after tissue is formed: A deformation is a condition arising from mechanical stress to normal tissue. [16] Deformations often occur in the second or third trimester, and can be due to oligohydramnios.
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