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Reuptake enhancer. A reuptake enhancer ( RE ), also sometimes referred to as a reuptake activator, is a type of reuptake modulator which enhances the plasmalemmal transporter -mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron, leading to a decrease in the extracellular concentrations of the neurotransmitter ...
H3K4me1 is a chromatin signature of enhancers, H3K4me2 is highest toward the 5′ end of transcribing genes and H3K4me3 is highly enriched at promoters and in poised genes. H3K27me3 , H4K20me1 and H3K4me1 silence transcription in embryonic fibroblasts, macrophages, and human embryonic stem cells (ESCs).
In genetics, an enhancer is a short (50–1500 bp) region of DNA that can be bound by proteins ( activators) to increase the likelihood that transcription of a particular gene will occur. [ 1][ 2] These proteins are usually referred to as transcription factors. Enhancers are cis -acting.
H3K27ac. H3K27ac is an epigenetic modification to the DNA packaging protein histone H3. It is a mark that indicates acetylation of the lysine residue at N-terminal position 27 of the histone H3 protein. H3K27ac is associated with the higher activation of transcription and therefore defined as an active enhancer mark.
CAG promoter. The CAG promoter is a strong synthetic promoter frequently used to drive high levels of gene expression in mammalian expression vectors. [ 1][ 2] CAG promoter was constructed in the lab of Dr Jun-ichi Miyazaki [ 3][ 4] from the following sequences: The resulting synthetic element was used in the pCAGGS expression vector.
Enhancer RNAs (eRNAs) represent a class of relatively long non-coding RNA molecules (50-2000 nucleotides) transcribed from the DNA sequence of enhancer regions. They were first detected in 2010 through the use of genome-wide techniques such as RNA-seq and ChIP-seq .
Eventually, the lactase will digest all of the lactose, until there is none to bind to the repressor. The repressor will then bind to the operator, stopping the manufacture of lactase. In genetics, a promoter is a sequence of DNA to which proteins bind to initiate transcription of a single RNA transcript from the DNA downstream of the promoter.
Exonic splicing enhancer. In molecular biology, an exonic splicing enhancer (ESE) is a DNA sequence motif consisting of 6 bases within an exon that directs, or enhances, accurate splicing of heterogeneous nuclear RNA ( hnRNA) or pre-mRNA into messenger RNA ( mRNA ).
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