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One of the issues faced by drug delivery is the solubility of the drug in the body; around 40% of newly detected chemicals found in drug discovery are poorly soluble in water. This low solubility affects the bioavailability of the drug, meaning the rate at which the drug reaches the circulatory system and thus the target site.
Taken orally, 20 mg of immediate-release oxycodone is considered to be equivalent in analgesic effect to 30 mg of morphine, [70] [71] while extended release oxycodone is considered to be twice as potent as oral morphine. [72] Similarly to most other opioids, oxycodone increases prolactin secretion, but its influence on testosterone levels is ...
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