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The Thirty Years' War [j] was one of the longest and most destructive conflicts in European history, lasting from 1618 to 1648. Fought primarily in Central Europe, an estimated 4.5 to 8 million soldiers and civilians died as a result of battle, famine, or disease, while parts of present-day Germany reported population declines of over 50%. [19]
A randomized controlled trial (or randomized control trial; [2] RCT) is a form of scientific experiment used to control factors not under direct experimental control. Examples of RCTs are clinical trials that compare the effects of drugs, surgical techniques, medical devices, diagnostic procedures, diets or other medical treatments.
The Black Death was a bubonic plague pandemic occurring in Europe from 1346 to 1353. It was one of the most fatal pandemics in human history; as many as 50 million people [2] perished, perhaps 50% of Europe's 14th century population. [3] The disease is caused by the bacterium Yersinia pestis and spread by fleas and through the air.
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