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Melatonin acts as an agonist of the melatonin MT 1 and MT 2 receptors, the biological targets of endogenous melatonin. [21] It is thought to activate these receptors in the suprachiasmatic nucleus of the hypothalamus in the brain to regulate the circadian clock and sleep–wake cycles. [21] Immediate-release melatonin has a short elimination half-life of about 20 to 50 minutes. [22] [9] [10 ...
Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.
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Kroger, which is in the process of looking for locations to open its first store, will face competition from Honolulu-based rivals Foodland and Times; major retailers Safeway, Walmart, and Costco; Japanese-owned Don Quixote; and Department of Defense-owned DeCA Commissaries.
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