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Specialty. Endocrinology. Maturity-onset diabetes of the young ( MODY) refers to any of several hereditary forms of diabetes mellitus caused by mutations in an autosomal dominant gene disrupting insulin production. [ 1] Along with neonatal diabetes, MODY is a form of the conditions known as monogenic diabetes.
MODY 2. MODY 2 or GCK-MODY is a form of maturity-onset diabetes of the young. [1] It is due to any of several mutations in the GCK gene on human chromosome 7 for glucokinase. [2] Glucokinase serves as the glucose sensor for the pancreatic beta cell. Normal glucokinase triggers insulin secretion as the glucose exceeds about 90 mg/dl (5 mM).
Modding. Modding (from modifying) is the act of modifying hardware, software, or anything else to perform a function not originally intended by the designer, or to achieve bespoke specification or appearance. The term is often used in reference to video game modding, particularly in regard to creating new or altered content and sharing that via ...
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Renal cysts and diabetes syndrome (RCAD), also known as MODY 5 or HNF1B-MODY, is a form of maturity onset diabetes of the young. Presentation [ edit ] HNF1β-related MODY is one of the less common forms of MODY, with some distinctive clinical features, including atrophy of the pancreas and several forms of renal disease.
MODY 3. MODY 3 or HNF1A-MODY is a form of maturity-onset diabetes of the young. It is caused by mutations of the HNF1-alpha gene, a homeobox gene on human chromosome 12. This is the most common type of MODY in populations with European ancestry, [1] accounting for about 70% of all cases in Europe. HNF1α is a transcription factor (also known as ...
The Android Package with the file extension apk[ 1] is the file format used by the Android operating system, and a number of other Android-based operating systems for distribution and installation of mobile apps, mobile games and middleware. A file using this format can be built from source code written in either Java or Kotlin .
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