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  2. Nirmatrelvir/ritonavir - Wikipedia

    en.wikipedia.org/wiki/Nirmatrelvir/ritonavir

    No participants had received a COVID‑19 vaccine or been previously infected with COVID‑19. [12] The main outcome measured in the trial was the proportion of people who were hospitalized due to COVID‑19 or died due to any cause during 28 days of follow-up. [12] EPIC-HR started in July 2021, and completed in December 2021. [46]

  3. Treatment and management of COVID-19 - Wikipedia

    en.wikipedia.org/wiki/Treatment_and_management...

    The treatment and management of COVID-19 combines both supportive care, which includes treatment to relieve symptoms, fluid therapy, oxygen support as needed, [1] [2] [3] and a growing list of approved medications. Highly effective vaccines have reduced mortality related to SARS-CoV-2; however, for those awaiting vaccination, as well as for the ...

  4. Remdesivir - Wikipedia

    en.wikipedia.org/wiki/Remdesivir

    In the United States, remdesivir is indicated for the treatment of COVID‑19 in people 28 days of age and older and weighing at least 3 kilograms (6.6 lb) who are hospitalized; or not hospitalized and have mild-to-moderate COVID‑19, and are at high risk for progression to severe COVID‑19, including hospitalization or death. [12] [25]

  5. Molnupiravir - Wikipedia

    en.wikipedia.org/wiki/Molnupiravir

    Molnupiravir. Molnupiravir, sold under the brand name Lagevrio, is an antiviral medication that inhibits the replication of certain RNA viruses. [ 7] It is used to treat COVID‑19 in those infected by SARS-CoV-2. [ 7] It is taken by mouth. [ 7] Molnupiravir is a prodrug of the synthetic nucleoside derivative N4 -hydroxy cytidine and exerts its ...

  6. Nirmatrelvir - Wikipedia

    en.wikipedia.org/wiki/Nirmatrelvir

    Nirmatrelvir. X-ray crystal structure ( PDB:7SI9 and 7VH8) of the SARS-CoV-2 protease inhibitor nirmatrelvir bound to the viral 3CLpro protease enzyme. Ribbon diagram of the protein with the drug shown as sticks. The catalytic residues (His41, Cys145) are shown as yellow sticks. Nirmatrelvir is an antiviral medication developed by Pfizer which ...

  7. List of antiviral drugs - Wikipedia

    en.wikipedia.org/wiki/List_of_antiviral_drugs

    COVID-19. Pfizer. 3C-like protease inhibitor (Nirmatrelvir) / inhibition of metabolism of nirmatrelvir (ritonavir) Nevirapine. HIV. non- nucleoside reverse transcriptase inhibitor. Nitazoxanide. Broad-spectrum antiviral.

  8. Ensitrelvir - Wikipedia

    en.wikipedia.org/wiki/Ensitrelvir

    Ensitrelvir is being studied for its potential use as post-exposure prophylaxis (PEP) after SARS-CoV-2 exposure. [19] [20] The SCORPIO-PEP trial is a global Phase 3 trial that will evaluate the safety and efficacy of the drug in preventing symptomatic SARS-CoV-2 infection in household contacts of people who tested positive for COVID-19.

  9. COVID-19 drug development - Wikipedia

    en.wikipedia.org/wiki/COVID-19_drug_development

    COVID-19 drug development is the research process to develop preventative therapeutic prescription drugs that would alleviate the severity of coronavirus disease 2019 (COVID-19). From early 2020 through 2021, several hundred drug companies, biotechnology firms, university research groups, and health organizations were developing therapeutic ...