Search results
Results From The WOW.Com Content Network
Subsequently, G2A was suggested to be a receptor for lysophosphatidylcholine (LPC). However, the roles of G2A as a pH-sensor or LPC receptor are disputed. Rather, current studies suggest that it is a receptor for certain metabolites of the polyunsaturated fatty acid, linoleic acid .
The receptor on the phagocyte that is thought to be linked to LPC is G2A, but it has not been confirmed. [8] The role of LPC as a find-me signal has also not been characterized in vivo. [3]
Proton-sensing G protein-coupled receptors are transmembrane receptors which sense acidic pH and include GPR132 (G2A), GPR4, GPR68 (OGR1) and GPR65 (TDAG8). [2] These G protein-coupled receptors are activated when extracellular pH falls into the range of 6.4-6.8 (typical values are above 7.0). The functional role of the low pH sensitivity of the proton-sensing G protein-coupled receptors is ...
G protein-coupled receptors are found only in eukaryotes, including yeast, and choanoflagellates. [4] The ligands that bind and activate these receptors include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters, and vary in size from small molecules to peptides to large proteins. G protein-coupled receptors are involved in many diseases.
Lysophospholipid receptor. The lysophospholipid receptor ( LPL-R) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. [1] In humans, there are eleven LPL receptors, each encoded by a separate gene. These LPL receptor genes are also sometimes referred to as " Edg " (an ...
The lysophosphatidic acid receptors ( LPARs) are a group of G protein-coupled receptors for lysophosphatidic acid (LPA) that include: Lysophosphatidic acid receptor 1 (LPAR1; formerly known as EDG2, GPR26)
Alpha-2 adrenergic receptor. The alpha-2 ( α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the G i heterotrimeric G-protein. It consists of three highly homologous subtypes, including α 2A -, α 2B -, and α 2C -adrenergic. Some species other than humans express a fourth α 2D -adrenergic ...
The adenosine A2A receptor has also been shown to play a regulatory role in the adaptive immune system. In this role, it functions similarly to programmed cell death-1 (PD-1) and cytotoxic t-lymphocyte associated protein-4 ( CTLA-4) receptors, namely to suppress immunologic response and prevent associated tissue damage.