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The coenzyme folic acid (top) and the anticancer drug methotrexate (bottom) are very similar in structure. As a result, methotrexate is a competitive inhibitor of many enzymes that use folates. Methotrexate (green) complexed into the active site of DHFR (blue) Methotrexate is an antimetabolite of the antifolate type. It is thought to affect ...
Folinic acid. Folinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine. [ 2][ 3] It is also used in combination with 5-fluorouracil to treat colorectal cancer and pancreatic cancer, may be used to treat folate deficiency that results in anemia, and methanol poisoning. [ 3][ 4 ...
Antifolate. Antifolates are a class of antimetabolite medications that antagonise (that is, block) the actions of folic acid (vitamin B 9 ). [ 1] Folic acid's primary function in the body is as a cofactor to various methyltransferases involved in serine, methionine, thymidine and purine biosynthesis. Consequently, antifolates inhibit cell ...
Yellapragada Subbarow [a] (12 January 1895 – 8 August 1948) was an Indian American biochemist who discovered the function of adenosine triphosphate (ATP) as an energy source in the cell, [1] developed methotrexate for the treatment of cancer and led the department at Lederle laboratories in which Benjamin Minge Duggar discovered chlortetracycline in 1945.
When methotrexate is prescribed, folic acid supplements are sometimes given with the methotrexate. The therapeutic effects of methotrexate are due to its inhibition of dihydrofolate reductase and thereby reduce the rate de novo purine and pyrimidine synthesis and cell division. Methotrexate inhibits cell division and is particularly toxic to ...
Folinic acid, under the drug name leucovorin, a form of folate (formyl-THF), can help "rescue" or reverse the toxic effects of methotrexate. [59] Folic acid supplements have little established role in cancer chemotherapy.
Antimetabolite. The drug methotrexate (bottom) is an antimetabolite that interferes with the metabolism of folic acid (top) An antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. [ 1] Such substances are often similar in structure to the metabolite that they interfere ...
Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate. [6] SLC19A1 has also been shown to transport the immune second messenger 2'3'-cGAMP.
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