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A blue circle, the symbol for diabetes. High blood sugar levels, autoantibodies targeting insulin-producing cells. Type 1 diabetes ( T1D ), formerly known as juvenile diabetes, is an autoimmune disease that originates when cells that make insulin (beta cells) are destroyed by the immune system. [ 5] Insulin is a hormone required for the cells ...
Slowly evolving immune-mediated diabetes, or latent autoimmune diabetes in adults ( LADA ), is a form of diabetes that exhibits clinical features similar to both type 1 diabetes (T1D) and type 2 diabetes (T2D), [ 3][ 4] and is sometimes referred to as type 1.5 diabetes. [ 5] It is an autoimmune form of diabetes, similar to T1D, but patients ...
Diabetes mellitus, often known simply as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. [ 10][ 11] Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body becoming unresponsive to the hormone's effects. [ 12] Classic symptoms include thirst, polyuria ...
Diabetic angiopathy is a form of angiopathy associated with diabetic complications. [ 1] While not exclusive, the two most common forms are diabetic retinopathy and diabetic nephropathy, whose pathophysiologies are largely identical. Other forms of diabetic angiopathy include diabetic neuropathy and diabetic cardiomyopathy. [ 2][ 3]
In the DCCT (Diabetes Control and Complications Trial, 1995) study, the annual incidence of neuropathy was 2% per year but dropped to 0.56% with intensive treatment of Type 1 diabetics. The progression of neuropathy is dependent on the degree of glycemic control in both Type 1 and Type 2 diabetes.
Specialty. Endocrinology. Maturity-onset diabetes of the young ( MODY) refers to any of several hereditary forms of diabetes mellitus caused by mutations in an autosomal dominant gene disrupting insulin production. [ 1] Along with neonatal diabetes, MODY is a form of the conditions known as monogenic diabetes.
Type 2 diabetes is different in that it is usually caused by insulin resistance in the body in older patients leading to beta cell burnout over time, and is not prone to DKA. KPD is a condition that involves DKA like type 1, but occurs later in life and can regain beta cell function like type 2 diabetes.
Diabetic nephropathy, also known as diabetic kidney disease, [ 5] is the chronic loss of kidney function occurring in those with diabetes mellitus. Diabetic nephropathy is the leading causes of chronic kidney disease (CKD) and end-stage renal disease (ESRD) globally. The triad of protein leaking into the urine (proteinuria or albuminuria ...