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Alpidem (Ananxyl) 1995. Worldwide. Not approved in the US, withdrawn in France in 1994 [4] and the rest of the market in 1995 because of rare but serious hepatotoxicity. [3] [5] Alosetron (Lotronex) 2000. US. Serious gastrointestinal adverse events; ischemic colitis; severe constipation. [2]
Target Canada filed for bankruptcy in 2015, selling its stores to Walmart, Lowe's and Canadian Tire. In 2016, the Hudson's Bay Company started opening Saks Off 5th locations to sell off-price brands. American off-price chain Nordstrom Rack opened its first Canadian location in Vaughan Mills in 2018. Food Basics discount supermarket.
Rank Drug Main indication Trade name 2018 sales (million USD) 2017 sales (million USD) 1 adalimumab: rheumatoid arthritis: Humira 19 936 18427 3 apixaban
Among individuals treated with a given antidepressant, between 30% and 50% do not show a response. Approximately one-third of people achieve a full remission, one-third experience a response, and one-third are non-responders. Partial remission is characterized by the presence of poorly defined residual symptoms.
Arguments that cannabis is a gateway drug. The US Drug Enforcement Agency's "2008 Marijuana Sourcebook" argues that recent research supports the gateway hypothesis that certain drugs (such as cannabis) act as gateways to use of 'harder' drugs such as heroin, either because of social contact or because of an increasing search for a better high.
Great Depression in Canada. A Montreal soup kitchen in 1931. The worldwide Great Depression of the early 1930s was a social and economic shock that left millions of Canadians unemployed, hungry and often homeless. Few countries were affected as severely as Canada during what became known as the "Dirty Thirties", due to Canada's heavy dependence ...
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