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  2. Thiazide - Wikipedia

    en.wikipedia.org/wiki/Thiazide

    Thiazide ( / ˈθaɪəzaɪd /) refers to both a class of sulfur-containing organic molecules [ 1] and a class of diuretics based on the chemical structure of benzothiadiazine. [ 2] The thiazide drug class was discovered and developed at Merck and Co. in the 1950s. [ 3] The first approved drug of this class, chlorothiazide, was marketed under ...

  3. Hydrochlorothiazide - Wikipedia

    en.wikipedia.org/wiki/Hydrochlorothiazide

    Hydrochlorothiazide. Hydrochlorothiazide, sold under the brand name Hydrodiuril among others, is a diuretic medication used to treat hypertension and swelling due to fluid build-up. [ 4] Other uses include treating diabetes insipidus and renal tubular acidosis and to decrease the risk of kidney stones in those with a high calcium level in the ...

  4. Thiazide diuretics have been commonly used as first-line agents for the treatment of hypertension. They have proven effective at lowering blood pressure, being safe, and being low cost.

  5. Chlortalidone - Wikipedia

    en.wikipedia.org/wiki/Chlortalidone

    Chlortalidone (or other thiazide medication) is a key component of treatment of nephrogenic diabetes insipidus. Nephrogenic diabetes insipidus occurs when the kidney is unable to concentrate urine because it has an inadequate response to vasopressin-dependent removal of free water from the renal tubular filtrate.

  6. Metolazone - Wikipedia

    en.wikipedia.org/wiki/Metolazone

    Metolazone is a thiazide-like diuretic marketed under the brand names Zytanix, Metoz, Zaroxolyn, and Mykrox. It is primarily used to treat congestive heart failure and high blood pressure. Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases.

  7. Diuretic - Wikipedia

    en.wikipedia.org/wiki/Diuretic

    Loop and thiazide diuretics are secreted from the proximal tubule via the organic anion transporter-1 and exert their diuretic action by binding to the Na(+)-K(+)-2Cl(-) co-transporter type 2 in the thick ascending limb and the Na(+)-Cl(-) co-transporter in the distal convoluted tubule, respectively.

  8. Indapamide - Wikipedia

    en.wikipedia.org/wiki/Indapamide

    Indapamide is a thiazide-like diuretic [ 4] drug used in the treatment of hypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are available. The thiazide-like diuretics (indapamide and chlorthalidone) reduce risk of major cardiovascular events and heart failure in ...

  9. Potassium-sparing diuretic - Wikipedia

    en.wikipedia.org/wiki/Potassium-sparing_diuretic

    Potassium-sparing diuretics or antikaliuretics[ 1] refer to drugs that cause diuresis without causing potassium loss in the urine. [ 2] They are typically used as an adjunct in management of hypertension, cirrhosis, and congestive heart failure. [ 3] The steroidal aldosterone antagonists can also be used for treatment of primary hyperaldosteronism.

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