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Non-24-hour sleep–wake disorder causes a person's sleep–wake cycle to move around the clock every day, to a degree dependent on the length of the cycle. This is known as free-running sleep. [citation needed] People with the disorder may have an especially hard time adjusting to changes in "regular" sleep–wake cycles, such as vacations ...
Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [ 1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.
It is thought to activate these receptors in the suprachiasmatic nucleus of the hypothalamus in the brain to regulate the circadian clock and sleep–wake cycles. [21] Immediate-release melatonin has a short elimination half-life of about 20 to 50 minutes. [22] [9] [10] Prolonged-release melatonin used as a medication has a half-life of 3.5 to ...
Sleep medicine is a medical specialty or subspecialty devoted to the diagnosis and therapy of sleep disturbances and disorders. [ 1] From the middle of the 20th century, research has provided increasing knowledge of, and answered many questions about, sleep–wake functioning. [ 2] The rapidly evolving field [ 3] has become a recognized medical ...
Sleep apnea is a sleep-related breathing disorder in which repetitive pauses in breathing, periods of shallow breathing, or collapse of the upper airway during sleep results in poor ventilation and sleep disruption. [ 10][ 11] Each pause in breathing can last for a few seconds to a few minutes and occurs many times a night. [ 1]
Obstructive sleep apnea ( OSA) is the most common sleep-related breathing disorder and is characterized by recurrent episodes of complete or partial obstruction of the upper airway leading to reduced or absent breathing during sleep. These episodes are termed "apneas" with complete or near-complete cessation of breathing, or "hypopneas" when ...
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