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GTPase-activating proteins or GTPase-accelerating proteins (GAPs) are a family of regulatory proteins whose members can bind to activated G proteins and stimulate their GTPase activity, with the result of terminating the signaling event. [1] GAPs are also known as RGS protein, or RGS proteins, [2] and these proteins are crucial in controlling ...
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Based on ComScore data 65% of eCommerce transactions in Q4 2017 in the United States were with free shipping. This figure has been consistent for the last few years (ranging between 58% and 69%). Moreover, US respondents asked in the survey listed free shipping (54% mentions) as a most important factor for online shipping.
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Biochemically, these mutations have been shown to similarly effect aberrant activation of the catalytic domain towards Ras-GTPases. This may be explained because the SOS1 protein adopts an auto-inhibited conformation dependent on multiple domain-to-domain interactions that cooperate to block access of the SOS1 catalytic core to its Ras-GTPase ...
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