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Alzheimer's disease ( AD) is a neurodegenerative disease that usually starts slowly and progressively worsens, [ 2] and is the cause of 60–70% of cases of dementia. [ 2][ 15] The most common early symptom is difficulty in remembering recent events. [ 1] As the disease advances, symptoms can include problems with language, disorientation ...
Neurology. Early-onset Alzheimer's disease ( EOAD ), also called younger-onset Alzheimer's disease ( YOAD ), [ 1] is Alzheimer's disease diagnosed before the age of 65. [ 2] It is an uncommon form of Alzheimer's, accounting for only 5–10% of all Alzheimer's cases. About 60% have a positive family history of Alzheimer's and 13% of them are ...
Dementia is a syndrome associated with many neurodegenerative diseases, characterized by a general decline in cognitive abilities that affects a person's ability to perform everyday activities. This typically involves problems with memory, thinking, behavior, and motor control. [ 10]
Alzheimer's disease (AD) is a chronic neurodegenerative disease that results in the loss of neurons and synapses in the cerebral cortex and certain subcortical structures, resulting in gross atrophy of the temporal lobe, parietal lobe, and parts of the frontal cortex and cingulate gyrus. [13]
Frontotemporal dementia ( FTD ), also called frontotemporal degeneration disease[ 1] or frontotemporal neurocognitive disorder,[ 2] encompasses several types of dementia involving the progressive degeneration of the brain's frontal and temporal lobes. [ 3] FTD is the second most prevalent type of early onset dementia after Alzheimer's disease ...
A new study has revealed that older age, female gender, irregular heart rhythms and daily activity levels can predict the severity of cognitive decline in people with Alzheimer’s disease and ...
Amyloid beta (Aβ) is a small protein, most often 40 or 42 amino acids in length, that is released from a longer parent protein called the Aβ-precursor protein (APP). [ 24] APP is produced by many types of cell in the body, but it is especially abundant in neurons. It is a single-pass transmembrane protein, passing once through cellular membranes.
The biomarkers can be used to diagnose Alzheimer's disease (AD) in a very early stage, but they also provide objective and reliable measures of disease progress. It is imperative to diagnose AD disease as soon as possible, because neuropathologic changes of AD precede the symptoms by years. [ 1] It is well known that amyloid beta (Aβ) is a ...