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Tramadol, sold under the brand name Ultram among others, [1] is an opioid pain medication and a serotonin–norepinephrine reuptake inhibitor (SNRI) used to treat moderately severe pain. [3] [14] When taken by mouth in an immediate-release formulation, the onset of pain relief usually begins within an hour. [3]
Rare (0.01–0.1% incidence) Bradycardia. Hypertension (high blood pressure) Allergic reactions (e.g. dyspnoea (shortness of breath), bronchospasm, wheezing, angioneurotic oedema) Anaphylaxis. Changes in appetite. Paraesthesia (pins and needles) Hallucinations. Tremor.
Tapentadol. Tapentadol, brand names Nucynta among others, is a centrally acting opioid analgesic of the benzenoid class with a dual mode of action as an agonist of the μ-opioid receptor and as a norepinephrine reuptake inhibitor (NRI). [4] Analgesia occurs within 32 minutes of oral administration, and lasts for 4–6 hours.
Pain ladder. "Pain ladder", or analgesic ladder, was created by the World Health Organization (WHO) as a guideline for the use of drugs in the management of pain. Originally published in 1986 for the management of cancer pain, it is now widely used by medical professionals for the management of all types of pain .
Opioid-induced hyperalgesia (OIH) or opioid-induced abnormal pain sensitivity, also called paradoxical hyperalgesia, is an uncommon condition of generalized pain caused by the long-term use of high dosages of opioids [1] such as morphine, [2] oxycodone, [3] and methadone. [4] [5] OIH is not necessarily confined to the original affected site. [6]
A complex hormonal connection. During menopause, your body and brain undergo some radical shifts that can contribute to the development of an eating disorder. New hormone fluctuations not only ...
Desmetramadol. Desmetramadol ( INN ), also known as O-desmethyltramadol ( O-DSMT ), is an opioid analgesic and the main active metabolite of tramadol. [2] Tramadol is demethylated by the liver enzyme CYP2D6 [3] to desmetramadol in the same way as codeine, and so similarly to the variation in effects seen with codeine, individuals who have a ...
Medco Health Solutions, Inc. was an American Pharmacy Benefits Management (PBM) company. Medco provided pharmacy services to private and public employers, health plans, labor unions, government agencies, and individuals served by Medicare Part D Prescription Drug Plans. Medco was a member of the S&P 500 and ranked number 34 on the 2011 Fortune ...
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