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Sleep medicine is a medical specialty or subspecialty devoted to the diagnosis and therapy of sleep disturbances and disorders. [1] From the middle of the 20th century, research has provided increasing knowledge of, and answered many questions about, sleep–wake functioning. [2] The rapidly evolving field [3] has become a recognized medical ...
Daridorexant, sold under the brand name Quviviq, is an orexin antagonist medication which is used for the treatment of insomnia. [1][4][6][7][8] Daridorexant is taken by mouth. [1][4][7] Side effects of daridorexant include headache, somnolence, and fatigue. [1][7] The medication is a dual orexin receptor antagonist (DORA). [9][7][10][8] It acts as a selective dual antagonist of the orexin ...
Relaxin is a protein hormone of about 6000 Da, [1] first described in 1926 by Frederick Hisaw. [2][3] The relaxin family peptide hormones belong to the insulin superfamily and consists of seven peptides of high structural but low sequence similarity; relaxin-1 (RLN1), 2 (RLN2) and 3 (RLN3), and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6. The functions of relaxin-3, INSL4 ...
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Medical uses. Suvorexant is used for the treatment of insomnia, characterized by difficulties with sleep onset and/or sleep maintenance, in adults. [2][6] At a dose of 15 to 20 mg and in terms of treatment– placebo difference, it reduces time to sleep onset by up to 10 minutes, reduces time awake after sleep onset by about 15 to 30 minutes ...
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