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15902 Ensembl ENSG00000115738 ENSMUSG00000020644 UniProt Q02363 P41136 RefSeq (mRNA) NM_002166 NM_010496 RefSeq (protein) NP_002157 NP_034626 Location (UCSC) Chr 2: 8.68 – 8.68 Mb Chr 12: 25.14 – 25.15 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene. Function The protein encoded by this gene ...
Four ID proteins exist in humans: ID1, ID2, ID3, and ID4. The ID homologue gene in Drosophila is called extramacrochaetae (EMC) and encodes a transcription factor of the helix-loop-helix family that lacks a DNA binding domain. EMC regulates cell proliferation, formation of organs like the midgut, and wing development.
ID1 has been shown to interact weakly with MyoD but very tightly with ubiquitously expressed E proteins. E proteins heterodimerize with tissue restricted bHLH proteins such as Myod, NeuroD, etc. to form active transcription complexes so by sequestering E proteins, Id proteins can inhibit tissue restricted gene expression in multiple cell lineages using the same biochemical mechanism.
Activation-induced cytidine deaminase, also known as AICDA, AID and single-stranded DNA cytosine deaminase, is a 24 kDa enzyme which in humans is encoded by the AICDA gene. [ 5] It creates mutations in DNA [ 6][ 7] by deamination of cytosine base, which turns it into uracil (which is recognized as a thymine ).
Innate lymphoid cell. Innate lymphoid cells ( ILCs) are the most recently discovered family of innate immune cells, derived from common lymphoid progenitors (CLPs). In response to pathogenic tissue damage, ILCs contribute to immunity via the secretion of signalling molecules, and the regulation of both innate and adaptive immune cells. ILCs are ...
ID4. ID4 is a protein coding gene. In humans, it encodes the protein known as DNA-binding protein inhibitor ID-4. [5] [6] This protein is known to be involved in the regulation of many cellular processes during both prenatal development and tumorigenesis.
Isocitrate dehydrogenase [NADP], mitochondrial is an enzyme that in humans is encoded by the IDH2 gene. [ 5] Isocitrate dehydrogenases are enzymes that catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD (+) as the electron acceptor and the other NADP
A similar screen done in the Caenorhabditis elegans protein SMA (from gene sma for small body size) revealed three genes, Sma-2, Sma-3, and Sma-4, that had similar mutant phenotypes to those of the TGF-B like receptor Daf-4. [11] The human homologue of Mad and Sma was named Smad1, a portmanteau of the previously discovered genes.
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