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  2. Triiodothyronine - Wikipedia

    en.wikipedia.org/wiki/Triiodothyronine

    In any case, the concentration of T 3 in the human blood plasma is about one-fortieth that of T 4. The half-life of T 3 is about 2.5 days. [3] The half-life of T 4 is about 6.5 days. [4] T 3 levels start to rise 45 minutes after administration and peak at about 2.5 hours.

  3. Hypothalamic–pituitary–thyroid axis - Wikipedia

    en.wikipedia.org/wiki/Hypothalamic–pituitary...

    The hypothalamic–pituitary–thyroid axis ( HPT axis for short, a.k.a. thyroid homeostasis or thyrotropic feedback control) is part of the neuroendocrine system responsible for the regulation of metabolism and also responds to stress. As its name suggests, it depends upon the hypothalamus, the pituitary gland, and the thyroid gland .

  4. Euthyroid sick syndrome - Wikipedia

    en.wikipedia.org/wiki/Euthyroid_sick_syndrome

    Euthyroid sick syndrome ( ESS) is a state of adaptation or dysregulation of thyrotropic feedback control [ 1] wherein the levels of T3 and/or T4 are abnormal, but the thyroid gland does not appear to be dysfunctional. This condition may result from allostatic responses of hypothalamus-pituitary-thyroid feedback control, dyshomeostatic disorders ...

  5. Thyroid hormones - Wikipedia

    en.wikipedia.org/wiki/Thyroid_hormones

    The major form of thyroid hormone in the blood is thyroxine (T 4), whose half-life of around one week [4] is longer than that of T 3. [5] In humans, the ratio of T 4 to T 3 released into the blood is approximately 14:1. [6] T 4 is converted to the active T 3 (three to four times more potent than T 4) within cells by deiodinases (5′-deiodinase).

  6. This protocol can save overheating patients. Few states ...

    www.aol.com/protocol-save-overheating-patients...

    The patient should remain in the ice bath until their body temperature falls to 102.2 degrees. Then, they can be transported to the hospital. Preparing for heat illness in a warming world

  7. Deiodinase - Wikipedia

    en.wikipedia.org/wiki/Deiodinase

    Intuitively, if plasma levels of T3 fall, there would be a compensatory rise in TSH, the secretion of which is inhibited by T3. However, because type 2 deiodinase mediates the conversion of T4 to T3 within the pituitary and CNS, and because caloric restriction does not affect this enzyme, local T3 levels in the pituitary are normal.Thus, the ...

  8. Iodothyronine deiodinase - Wikipedia

    en.wikipedia.org/wiki/Iodothyronine_deiodinase

    Iodothyronine deiodinase. Iodothyronine deiodinases ( EC 1.21.99.4 and EC 1.21.99.3) are a subfamily of deiodinase enzymes important in the activation and deactivation of thyroid hormones. Thyroxine (T 4 ), the precursor of 3,5,3'- triiodothyronine (T 3) is transformed into T 3 by deiodinase activity. T 3, through binding a nuclear thyroid ...

  9. Hyperthyroidism - Wikipedia

    en.wikipedia.org/wiki/Hyperthyroidism

    In the United States hyperthyroidism affects about 1.2% of the population. [3] Worldwide, hyperthyroidism affects 2.5% of adults. [8] It occurs between two and ten times more often in women. [1] Onset is commonly between 20 and 50 years of age. [2] Overall the disease is more common in those over the age of 60 years. [1]