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Thrombocythemia. In hematology, thrombocythemia is a condition of high platelet (thrombocyte) count in the blood. Normal count is in the range of 150 × 10 9 to 450 × 10 9 platelets per liter of blood, [1] but investigation is typically only considered if the upper limit exceeds 750 × 10 9 /L. When the cause is unknown, the term ...
One common definition of thrombocytopenia requiring emergency treatment is a platelet count below 50,000/μL. [5] Thrombocytopenia can be contrasted with the conditions associated with an abnormally high level of platelets in the blood – thrombocythemia (when the cause is unknown), and thrombocytosis (when the cause is known). [6] [7]
Pseudothrombocytopenia. Pseudothrombocytopenia (PTCP) or spurious thrombocytopenia is an in-vitro sampling problem which may mislead the diagnosis towards the more critical condition of thrombocytopenia. The phenomenon may occur when the anticoagulant used while testing the blood sample causes clumping of platelets which mimics a low platelet ...
Immune thrombocytopenic purpura. Immune thrombocytopenic purpura ( ITP ), also known as idiopathic thrombocytopenic purpura or immune thrombocytopenia, is an autoimmune primary disorder of hemostasis characterized by a low platelet count in the absence of other causes. [1] [2] ITP often results in an increased risk of bleeding from mucosal ...
Frequency. 0.6-2.5/100,000 cases per year. [ 2] In hematology, essential thrombocythemia ( ET) is a rare chronic blood cancer ( myeloproliferative neoplasm) characterised by the overproduction of platelets (thrombocytes) by megakaryocytes in the bone marrow. [ 3] It may, albeit rarely, develop into acute myeloid leukemia or myelofibrosis. [ 3]
A myelodysplastic syndrome ( MDS) is one of a group of cancers in which immature blood cells in the bone marrow do not mature, and as a result, do not develop into healthy blood cells. [ 3] Early on, no symptoms typically are seen. [ 3] Later, symptoms may include fatigue, shortness of breath, bleeding disorders, anemia, or frequent infections ...
Giant platelet disorders, also known as macrothrombocytopenia, are rare disorders featuring abnormally large platelets, thrombocytopenia and a tendency to bleeding. Giant platelets cannot stick adequately to injured blood vessel walls, resulting in abnormal bleeding when injured. Giant platelet disorder occurs for inherited diseases like ...
Thrombotic microangiopathy ( TMA) is a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury. [ 1] It may be seen in association with thrombocytopenia, anemia, purpura and kidney failure . The classic TMAs are hemolytic uremic syndrome and thrombotic thrombocytopenic purpura.