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The thyroid receptors bind to response elements in gene promoters, thus enabling them to activate or inhibit transcription. The sensitivity of a tissue to T 3 is modulated through the thyroid receptors. Transportation The system of the thyroid hormones T 3 and T 4. T 3 and T 4 are carried in the blood
Levothyroxine. Levothyroxine, also known as L-thyroxine, is a synthetic form of the thyroid hormone thyroxine (T 4 ). [5] [8] It is used to treat thyroid hormone deficiency (hypothyroidism), including a severe form known as myxedema coma. [5] It may also be used to treat and prevent certain types of thyroid tumors. [5]
The thyroid hormones cross the follicular cell membrane towards the blood vessels by an unknown mechanism. Text books have stated that diffusion is the main means of transport, [35] but recent studies indicate that monocarboxylate transporter (MCT) 8 and 10 play major roles in the efflux of the thyroid hormones from the thyroid cells.
Propylthiouracil is in the antithyroid family of medications. [4] It works by decreasing the amount of thyroid hormone produced by the thyroid gland and blocking the conversion of thyroxine (T4) to triiodothyronine (T3). [3] Propylthiouracil came into medical use in the 1940s. [5]
of or relating to a blood clot, clotting of blood Greek θρόμβος (thrómbos), lump, piece, clot of blood thrombus, thrombocytopenia: thyr(o)-thyroid: Greek θῠρεός (thureós), large oblong shield; + εἶδος (eîdos), a form or shape thym-emotions Greek θῡμός (thūmós), spirit, soul; courage; breath, mind, emotions ...
Euthyroid sick syndrome. Euthyroid sick syndrome ( ESS) is a state of adaptation or dysregulation of thyrotropic feedback control [1] wherein the levels of T3 and/or T4 are abnormal, but the thyroid gland does not appear to be dysfunctional. This condition may result from allostatic responses of hypothalamus-pituitary-thyroid feedback control ...
Sepsis, infectious disease [1] Prognosis. 8-25% mortality with treatment; 80-100% mortality if untreated. Thyroid storm is a rare but severe and life-threatening complication of hyperthyroidism. It occurs when an overactive thyroid leads to hypermetabolism, which can cause death from cardiac arrest or multiple organ failure.
Myxedema coma is an extreme or decompensated form of hypothyroidism and while uncommon, is potentially lethal. [1] [2] [3] A person may have laboratory values identical to a "normal" hypothyroid state, but a stressful event (such as an infection, myocardial infarction, or stroke) precipitates the myxedema coma state, usually in the elderly.