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Activated protein C resistance ( APCR) is a hypercoagulability (an increased tendency of the blood to clot) characterized by a lack of a response to activated protein C (APC), which normally helps prevent blood from clotting excessively. This results in an increased risk of venous thrombosis (blood clots in veins), which resulting in medical ...
The activated protein C resistance ( APCR) test is a coagulation test used in the evaluation and diagnosis of activated protein C (APC) resistance, a form of hypercoagulability. [1] [2] Hereditary APC resistance is usually caused by the factor V Leiden mutation, whereas acquired APC resistance has been linked to antiphospholipid antibodies ...
Activated protein C–protein C inhibitor ( APC-PCI) is a complex of activated protein C (APC) and protein C inhibitor (PCI). [1] [2] [3] It has been measured in coagulation testing to evaluate coagulation, thrombosis, and other cardiovascular complications. [2] [3] [4] It is a marker of thrombin generation and indicates hypercoagulability.
Protein C. Protein C, also known as autoprothrombin IIA and blood coagulation factor XIV, [5] : 6822 [6] is a zymogen, that is, an inactive enzyme. The activated form plays an important role in regulating anticoagulation, inflammation, and cell death and maintaining the permeability of blood vessel walls in humans and other animals.
Lupus anticoagulant is an immunoglobulin [1] that binds to phospholipids and proteins associated with the cell membrane. Its name is a partial misnomer, as it is actually a prothrombotic antibody in vivo. The name derives from their properties in vitro, as these antibodies increase coagulation times in laboratory tests such as the activated ...
In probability theory, the coupon collector's problem refers to mathematical analysis of "collect all coupons and win" contests. It asks the following question: if each box of a given product (e.g., breakfast cereals) contains a coupon, and there are n different types of coupons, what is the probability that more than t boxes need to be bought ...
Ambulatory Payment Classification. APCs or Ambulatory Payment Classifications are the United States government's method of paying for facility outpatient services for the Medicare (United States) program. A part of the Federal Balanced Budget Act of 1997 made the Centers for Medicare and Medicaid Services create a new Medicare "Outpatient ...
Endothelial protein C receptor (EPCR) also known as activated protein C receptor (APC receptor) is a protein that in humans is encoded by the PROCR gene. [5] [6] [7] PROCR has also recently been designated CD201 ( cluster of differentiation 201). EPCR is a transmembrane glycoprotein receptor that plays a crucial role in regulation of blood ...