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About half of the cases are of unknown cause, with the other half attributable to a predisposing condition or medications being taken. Contrary to cold autoimmune hemolytic anemia (e.g., cold agglutinin disease and paroxysmal cold hemoglobinuria) which happens in cold temperature (28–31 °C), WAIHA happens at body temperature. [citation needed]
Hematology. Autoimmune hemolytic anemia ( AIHA) is an autoimmune disorder which occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst ( lyse ), leading to an insufficient number of oxygen-carrying red blood cells in circulation ( anemia ). The lifetime of the RBCs is reduced from the normal 100 ...
54,200 (2015) [ 7] Iron-deficiency anemia is anemia caused by a lack of iron. [ 3] Anemia is defined as a decrease in the number of red blood cells or the amount of hemoglobin in the blood. [ 3] When onset is slow, symptoms are often vague such as feeling tired, weak, short of breath, or having decreased ability to exercise. [ 1]
Hemolytic anemia or haemolytic anaemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells (RBCs), either in the blood vessels (intravascular hemolysis) or elsewhere in the human body (extravascular). [ 2] This most commonly occurs within the spleen, but also can occur in the reticuloendothelial system or ...
Anemia is the most common blood disorder, affecting about a fifth to a third of the global population. [1] [2] [11] [12] Iron-deficiency anemia is the most common cause of anemia worldwide, and affects nearly one billion people. [13] In 2013, anemia due to iron deficiency resulted in about 183,000 deaths – down from 213,000 deaths in 1990. [14]
Hematology. Cold agglutinin disease ( CAD) is a rare autoimmune disease characterized by the presence of high concentrations of circulating cold sensitive antibodies, usually IgM and autoantibodies that are also active at temperatures below 30 °C (86 °F), [ 1] directed against red blood cells, causing them to agglutinate and undergo lysis ...
Pathophysiology. Cold agglutinins, or cold autoantibodies, occur naturally in nearly all individuals. These natural cold autoantibodies occur at low titers, less than 1:64 measured at 4 °C, and have no activity at higher temperatures. Pathologic cold agglutinins occur at titers over 1:1000 and react at 28-31 °C and sometimes at 37 °C.
Alloimmune hemolytic anemia [1] Hemolytic disease of the newborn (HDN) [1] Rh disease (Rh D) [1] ABO hemolytic disease of the newborn [1] Anti-Kell hemolytic disease of the newborn [1] Rhesus c hemolytic disease of the newborn [1] Rhesus E hemolytic disease of the newborn [1] Other blood group incompatibility (RhC, Rhe, Kidd, Duffy, MN, P and ...
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