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Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.
Melatonin is a dietary supplement and medication as well as naturally occurring hormone. [9] [12] As a hormone, melatonin is released by the pineal gland and is involved in sleep–wake cycles. [9] [12] As a supplement, it is often used for the attempted short-term treatment of disrupted sleep patterns, such as from jet lag or shift work, and ...
The primary use of trazodone is the treatment of unipolar major depression with or without anxiety. [5] Data from open and double-blind trials suggest that the antidepressant efficacy of trazodone is comparable to that of amitriptyline, doxepin, and mianserin. Furthermore, trazodone has shown anxiolytic properties, low cardiotoxicity, and ...
Zaleplon, sold under the brand name Sonata among others, is a sedative and hypnotic which is used to treat insomnia. It is a nonbenzodiazepine or Z-drug of the pyrazolopyrimidine class. [6] It was developed by King Pharmaceuticals and approved for medical use in the United States in 1999. [3]
Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping. [1] They may have difficulty falling asleep, or staying asleep for as long as desired. [1] [9] [11] Insomnia is typically followed by daytime sleepiness, low energy, irritability, and a depressed mood. [1] It may result in an increased risk of ...
The Sleep Foundation states that herb has been shown to safely improve relaxation and sleep, but should always be used with caution and should not be used long term or with other sleep aids ...
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