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Zolpidem is a nonbenzodiazepine or Z-drug which acts as a sedative and hypnotic. [ 10][ 16] Zolpidem is a GABA A receptor agonist of the imidazopyridine class. [ 10] It works by increasing GABA effects in the central nervous system by binding to GABA A receptors at the same location as benzodiazepines. [ 10]
The guidelines found that temazepam at a dose of 15 mg reduces sleep latency by 37 minutes (95% CI Tooltip confidence interval 21 to 53 minutes), increases total sleep time by 99 minutes (95% CI 63 to 135 minutes), and provides a small improvement to sleep quality. [19]
Zopiclone, sold under the brand name Imovane among others, is a nonbenzodiazepine, specifically cyclopyrrolones, used to treat difficulty sleeping. Zopiclone is molecularly distinct from benzodiazepine drugs and is classed as a cyclopyrrolone. However, zopiclone increases the normal transmission of the neurotransmitter gamma-aminobutyric acid ...
Chemical structure of the prototypical Z-drug zolpidem. Nonbenzodiazepines (/ ˌ n ɒ n ˌ b ɛ n z oʊ d aɪ ˈ æ z ɪ p iː n,-ˈ eɪ-/ [1] [2]), sometimes referred to colloquially as Z-drugs (as many of their names begin with the letter "z"), are a class of psychoactive, depressant, sedative, hypnotic, anxiolytic drugs that are benzodiazepine-like in uses, such as for treating insomnia [3 ...
Oxazepam. Oxazepam is a short-to-intermediate-acting benzodiazepine. [ 7][ 8] Oxazepam is used for the treatment of anxiety [ 9][ 10] and insomnia and in the control of symptoms of alcohol withdrawal syndrome . It is a metabolite of diazepam, prazepam, and temazepam, [ 11] and has moderate amnesic, anxiolytic, anticonvulsant, hypnotic, sedative ...
When it comes to prescription sleep aids, such as Ambien (zolpidem), Sonata (zaleplon), and Restoril (temazepam, a highly addictive benzodiazepine), all are explicitly not to be used in children.
It is a popular drug of abuse in countries where it is available. [42] [43] [44] Doses as low as 5 mg can impair driving skills. [33] Therefore, people driving or conducting activities which require vigilance should exercise caution in using nitrazepam or possibly avoid it altogether. [45]
Suvorexant is used for the treatment of insomnia, characterized by difficulties with sleep onset and/or sleep maintenance, in adults. [2] [6] At a dose of 15 to 20 mg and in terms of treatment–placebo difference, it reduces time to sleep onset by up to 10 minutes, reduces time awake after sleep onset by about 15 to 30 minutes, and increases total sleep time by about 10 to 20 minutes. [2]
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