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Sirtuin. Sirtuins are a family of signaling proteins involved in metabolic regulation. [ 2][ 3] They are ancient in animal evolution and appear to possess a highly conserved structure throughout all kingdoms of life. [ 2] Chemically, sirtuins are a class of proteins that possess either mono- ADP-ribosyltransferase or deacylase activity ...
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Sirtuin 6 (SIRT6 or Sirt6) is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. [ 5 ] [ 6 ] [ 7 ] In laboratory research, SIRT6 appears to function in multiple molecular pathways related to aging, including DNA repair, telomere maintenance, glycolysis and inflammation . [ 5 ]
Sirtuin-activating compound. Sirtuin-activating compounds ( STAC) are chemical compounds having an effect on sirtuins, a group of enzymes that use NAD+ to remove acetyl groups from proteins. They are caloric restriction mimetic compounds that may be helpful in treating various aging -related diseases. [ 1]
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SIR proteins. Silent Information Regulator ( SIR) proteins are involved in regulating gene expression. SIR proteins organize heterochromatin near telomeres, [1] ribosomal DNA (rDNA), [2] and at silent loci including hidden mating type loci in yeast. [3] [4] The SIR family of genes encodes catalytic and non-catalytic proteins that are involved ...
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Sirtuin 3. NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)]. [ 5][ 6] SIRT3 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein.