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Ketamine potentiates the sedative effects of propofol [85] and midazolam. [86] Naltrexone potentiates psychotomimetic effects of a low dose of ketamine, [87] while lamotrigine [38] and nimodipine [39] decrease them. Clonidine reduces the increase of salivation, heart-rate and blood-pressure during ketamine anesthesia and decreases the incidence ...
Ketamine, one of the most popular NMDA receptor antagonists. NMDA receptor antagonists are a class of drugs that work to antagonize, or inhibit the action of, the N -Methyl- D -aspartate receptor ( NMDAR ). They are commonly used as anesthetics for humans and animals; the state of anesthesia they induce is referred to as dissociative anesthesia.
The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989 by a group led by pharmacologist David Bailey. Their first published clinical report on grapefruit drug interactions was in 1991. [9] The effect was first discovered accidentally in 1989, when a test of drug interactions with alcohol used grapefruit ...
The high levels of ketamine found in his blood could cause "lethal effects" from cardiovascular overstimulation and respiratory depression, the Los Angeles County medical examiner said in a report.
The amount is a low dose so patients are conscious and awake the entire time. Ketamine therapy primarily treats depression, PTSD, anxiety, suicidality, and other mental health conditions. Most ...
Ketamine can quickly ease depression and soothe suicidal thoughts in the short term, research has revealed. Analysis of 83 research papers showed that patients’ symptoms were reduced in just one ...
e. Ketamine-assisted psychotherapy (KAP) is the use of prescribed doses of ketamine, the drug, as an adjunct to psychotherapy sessions. KAP shows significant potential in treating mental disorders such as treatment-resistant depression (TRD), anxiety, obsessive–compulsive disorders (OCD), post-traumatic stress disorders (PTSD), and other ...
Self-harm, suicide. Treatment-resistant depression (TRD) is major depressive disorder in which an affected person does not respond adequately to at least two different antidepressant medications at an adequate dose and for an adequate duration. [1] Inadequate response has most commonly been defined as less than 25% reduction in depressive ...
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