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Factor V Leiden ( rs6025 or F5 p.R506Q[ 1]) is a variant (mutated form) of human factor V (one of several substances that helps blood clot), which causes an increase in blood clotting ( hypercoagulability ). Due to this mutation, protein C, an anticoagulant protein that normally inhibits the pro-clotting activity of factor V, is not able to ...
Factor V. Coagulation factor V ( Factor V ), also less commonly known as proaccelerin or labile factor, is a protein involved in coagulation, encoded, in humans, by F5 gene. [ 5] In contrast to most other coagulation factors, it is not enzymatically active but functions as a cofactor. [ 5] Factor V deficiency leads to predisposition for ...
Haemophilia. Haemophilia ( British English ), or hemophilia ( American English) [ 6] (from Ancient Greek αἷμα (haîma) 'blood' and φιλία (philía) 'love of'), [ 7] is a mostly inherited genetic disorder that impairs the body's ability to make blood clots, a process needed to stop bleeding. [ 2][ 3] This results in people bleeding for ...
Thrombophilia. An ultrasound image demonstrating a blood clot in the left common femoral vein. Thrombophilia (sometimes called hypercoagulability or a prothrombotic state) is an abnormality of blood coagulation that increases the risk of thrombosis (blood clots in blood vessels). [ 1][ 2] Such abnormalities can be identified in 50% of people ...
6947. Iron-deficiency anemia (or iron deficiency anaemia) is a common anemia that occurs when iron loss (often from intestinal bleeding or menses) occurs, and/or the dietary intake or absorption of iron is insufficient. In such a state, hemoglobin, which contains iron, cannot be formed. [ 5] Plummer–Vinson syndrome.
Von Willebrand disease ( VWD) is the most common hereditary blood-clotting disorder in humans. An acquired form can sometimes result from other medical conditions. [ 1] It arises from a deficiency in the quality or quantity of von Willebrand factor (VWF), a multimeric protein that is required for platelet adhesion.
Antiphospholipid syndrome, or antiphospholipid antibody syndrome ( APS or APLS ), is an autoimmune, hypercoagulable state caused by antiphospholipid antibodies. APS can lead to blood clots ( thrombosis) in both arteries and veins, pregnancy-related complications, and other symptoms like low platelets, kidney disease, heart disease, and rash.
Haemophilia B. This condition is inherited in an X-linked recessive manner. Haemophilia B, also spelled hemophilia B, is a blood clotting disorder causing easy bruising and bleeding due to an inherited mutation of the gene for factor IX, and resulting in a deficiency of factor IX. It is less common than factor VIII deficiency ( haemophilia A ).
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