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Sirtuin 2. NAD-dependent deacetylase sirtuin 2 is an enzyme that in humans is encoded by the SIRT2 gene. [5] [6] [7] SIRT2 is an NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase. Studies of this protein have often been divergent, highlighting the dependence of pleiotropic effects of SIRT2 on cellular context.
Sirtuin. Sirtuins are a family of signaling proteins involved in metabolic regulation. [ 2][ 3] They are ancient in animal evolution and appear to possess a highly conserved structure throughout all kingdoms of life. [ 2] Chemically, sirtuins are a class of proteins that possess either mono- ADP-ribosyltransferase or deacylase activity ...
Sirtuin-activating compound. Sirtuin-activating compounds ( STAC) are chemical compounds having an effect on sirtuins, a group of enzymes that use NAD+ to remove acetyl groups from proteins. They are caloric restriction mimetic compounds that may be helpful in treating various aging -related diseases. [ 1]
Getrag F23 transmission. The F23 is a five-speed manual transmission manufactured by Getrag in Italy. [citation needed] It is designed for transverse engine applications, primarily by General Motors. It can handle torque inputs of over 230 newton-metres (170 lbf⋅ft ). The F23 has one roll pin, two gearsets on each of three parallel shafts ...
Sirtuin 6. Sirtuin 6 ( SIRT6 or Sirt6) is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. [ 5][ 6][ 7] In laboratory research, SIRT6 appears to function in multiple molecular pathways related to aging, including DNA repair, telomere maintenance, glycolysis and inflammation. [ 5]
Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. [5] [6] [7]SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast (Saccharomyces cerevisiae) is Sir2.
Sirtuin 3. NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)]. [ 5][ 6] SIRT3 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein.
Automated manual transmissions can be semi-automatic or fully-automatic in operation. Several different systems to automate the clutch and/or shifting have been used over the years, but they will generally use one of the following methods of actuation for the clutch and/or shifting: hydraulic or electro-hydraulic actuation, [12] electro-mechanical, [13] pneumatic, [6] [14] [15] electromagnetic ...