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Sirtuin 2. NAD-dependent deacetylase sirtuin 2 is an enzyme that in humans is encoded by the SIRT2 gene. [5] [6] [7] SIRT2 is an NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase. Studies of this protein have often been divergent, highlighting the dependence of pleiotropic effects of SIRT2 on cellular context.
Sirtuin. Sirtuins are a family of signaling proteins involved in metabolic regulation. [ 2][ 3] They are ancient in animal evolution and appear to possess a highly conserved structure throughout all kingdoms of life. [ 2] Chemically, sirtuins are a class of proteins that possess either mono- ADP-ribosyltransferase or deacylase activity ...
Sirtuin-activating compound. Sirtuin-activating compounds ( STAC) are chemical compounds having an effect on sirtuins, a group of enzymes that use NAD+ to remove acetyl groups from proteins. They are caloric restriction mimetic compounds that may be helpful in treating various aging -related diseases. [ 1]
Sirtris Pharmaceuticals, Inc. was a biotechnology company based in Cambridge, MA that developed therapies for type 2 diabetes, cancer, and other diseases. Conceived in 2004 by Harvard University biologist David Sinclair and Andrew Perlman, [1] and founded that year by Sinclair and Perlman, along with Christoph Westphal, Richard Aldrich, Richard Pops, and Paul Schimmel, [2] the company was ...
SIR proteins. Silent Information Regulator ( SIR) proteins are involved in regulating gene expression. SIR proteins organize heterochromatin near telomeres, [1] ribosomal DNA (rDNA), [2] and at silent loci including hidden mating type loci in yeast. [3] [4] The SIR family of genes encodes catalytic and non-catalytic proteins that are involved ...
Sirtuin 6. Sirtuin 6 ( SIRT6 or Sirt6) is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. [ 5][ 6][ 7] In laboratory research, SIRT6 appears to function in multiple molecular pathways related to aging, including DNA repair, telomere maintenance, glycolysis and inflammation. [ 5]
The sugar could be produced as a hair gel, the study researcher (not pictured) suggested. Dr. John Whyte, WebMD's chief medical officer in Washington, D.C., called the study findings "intriguing ...
Doping in sport. The government of the German Democratic Republic (GDR) conducted a decades-long program of coercive administration and distribution of performance-enhancing drugs, initially testosterone, later mainly anabolic drugs, to its elite athletes. The aim of the program, which began in the 1960s, was to bolster East Germany's state ...