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Steam is a video game digital distribution service and storefront managed by Valve.It was launched as a software client in September 2003 to provide game updates automatically for Valve's games and expanded to distributing third-party titles in late 2005.
The intravenous dose causing 50% of opioid-naive experimental subjects to die (LD 50) is "3 mg/kg in rats, 1 mg/kg in cats, 14 mg/kg in dogs, and 0.03 mg/kg in monkeys." [ 96 ] The LD 50 in mice has been given as 6.9 mg/kg by intravenous administration, 17.5 mg/kg intraperitoneally, 27.8 mg/kg by oral administration. [ 97 ]
The state's annexation set off a chain of events that led to the Mexican–American War in 1846. Following victory by the United States, Texas remained a slave state until the American Civil War , when it declared its secession from the Union in early 1861 before officially joining the Confederate States of America on March 2.
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