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The International Classification of Diseases for Oncology ( ICD-O) is a domain-specific extension of the International Statistical Classification of Diseases and Related Health Problems for tumor diseases. This classification is widely used by cancer registries . It is currently in its third revision (ICD-O-3).
Ewing sarcoma is a small-blue-round-cell tumor that typically has a clear cytoplasm on H&E staining, due to glycogen. The presence of the glycogen can be demonstrated with positive PAS staining and negative PAS diastase staining. The characteristic immunostain is CD99, which diffusely marks the cell membrane.
CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3. [ 5] It is ubiquitously expressed in many tissues and cell types. [ 6] The gene codes for two proteins, including the INK4 family member p16 (or p16INK4a) and p14arf. [ 7]
Waldenström macroglobulinemia (/ ˈ v æ l d ən s t r ɒ m ˌ m æ k r oʊ ˌ ɡ l ɒ b j ə l ɪ ˈ n iː m i ə / VAL-dən-strom MAK-roh-GLOB-yə-lin-EE-mee-ə, [1] [2] US also / ˈ v ɑː l d ən s t r ɛ m-/ VAHL-dən-strem - [3]) is a type of cancer affecting two types of B cells: lymphoplasmacytoid cells and plasma cells.
Combined small cell lung carcinoma (or c-SCLC) is a form of multiphasic lung cancer that is diagnosed by a pathologist when a malignant tumor, arising from transformed cells originating in lung tissue, contains a component of;small cell lung carcinoma (SCLC), admixed with one (or more) components of any histological variant of non-small cell lung carcinoma (NSCLC) in any relative proportion.
HeLa ( / ˈhiːlɑː /) is an immortalized cell line used in scientific research. It is the oldest human cell line and one of the most commonly used. [ 1][ 2] HeLa cells are durable and prolific, allowing for extensive applications in scientific study. [ 3][ 4] The line is derived from cervical cancer cells taken on February 8, 1951, [ 5] from ...
NCI/ADR-RES appears to have been derived at some point in time from cell line OVCAR-8. Originally the cell line was named MCF-7/ADR-RES; it was renamed together with the change in classification. Two brain cancer cell lines, SNB-19 and U251, were discovered to come from the same person. This makes a mixup likely.
Cancer cell lines are originally derived from patient tumors, but acquire the ability to proliferate within in vitro cell cultures. As a result of in vitro manipulation, cell lines that have been traditionally used in cancer research undergo genetic transformations that are not restored when cells are allowed to grow in vivo. [9]