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Hybridoma technology is a method for producing large numbers of identical antibodies, also called monoclonal antibodies. This process starts by injecting a mouse (or other mammal) with an antigen that provokes an immune response. A type of white blood cell, the B cell, produces antibodies that bind to the injected antigen.
HeLa ( / ˈhiːlɑː /) is an immortalized cell line used in scientific research. It is the oldest human cell line and one of the most commonly used. [ 1][ 2] HeLa cells are durable and prolific, allowing for extensive applications in scientific study. [ 3][ 4] The line is derived from cervical cancer cells taken on February 8, 1951, [ 5] from ...
The International Classification of Diseases for Oncology (ICD-O) is a domain-specific extension of the International Statistical Classification of Diseases and Related Health Problems for tumor diseases. This classification is widely used by cancer registries. It is currently in its third revision (ICD-O-3). ICD-10 includes a list of ...
Waldenström macroglobulinemia (/ ˈ v æ l d ən s t r ɒ m ˌ m æ k r oʊ ˌ ɡ l ɒ b j ə l ɪ ˈ n iː m i ə / VAL-dən-strom MAK-roh-GLOB-yə-lin-EE-mee-ə, [1] [2] US also / ˈ v ɑː l d ən s t r ɛ m-/ VAHL-dən-strem - [3]) is a type of cancer affecting two types of B cells: lymphoplasmacytoid cells and plasma cells.
NCI/ADR-RES appears to have been derived at some point in time from cell line OVCAR-8. Originally the cell line was named MCF-7/ADR-RES; it was renamed together with the change in classification. Two brain cancer cell lines, SNB-19 and U251, were discovered to come from the same person. This makes a mixup likely.
Patient derived xenograft. Patient derived xenografts ( PDX) are models of cancer where the tissue or cells from a patient's tumor are implanted into an immunodeficient or humanized mouse. [ 1] It is a form of xenotransplantation. PDX models are used to create an environment that allows for the continued growth of cancer after its removal from ...
U937 (cell line) U-937 cells are a pro-monocytic model cell line used in biomedical research. [ 1] They were isolated from the histiocytic lymphoma of a 37-year-old male patient in 1974. [ 2] Due to the relative uniformity of expanded cultures and lower maintenance requirements these cells have been since used as an important tool for studying ...
Isogenic human disease models. Isogenic human disease models are a family of cells that are selected or engineered to accurately model the genetics of a specific patient population, in vitro. They are provided with a genetically matched 'normal cell' to provide an isogenic system to research disease biology and novel therapeutic agents. [ 1]