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Characteristics. HCT116 cells have a mutation in codon 13 of the KRAS proto-oncogene, and are suitable transfection targets for gene therapy research. [ 2] The cells have an epithelial morphology and can metastasize in xenograft models. [ 1] When transducted with viral vectors carrying the p53 gene, HCT116 cells remain arrested in the G1 phase ...
The International Classification of Diseases for Oncology (ICD-O) is a domain-specific extension of the International Statistical Classification of Diseases and Related Health Problems for tumor diseases. This classification is widely used by cancer registries. It is currently in its third revision (ICD-O-3). ICD-10 includes a list of ...
MCF-7. MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old White woman. [ 1] MCF-7 is the acronym of Michigan Cancer Foundation-7, referring to the institute in Detroit where the cell line was established in 1973 by Herbert Soule and co-workers. [ 2] The Michigan Cancer Foundation is now known as the Barbara Ann Karmanos ...
Atypical teratoid rhabdoid tumor. An atypical teratoid rhabdoid tumor ( AT/RT) is a rare tumor usually diagnosed in childhood. Although usually a brain tumor, AT/RT can occur anywhere in the central nervous system (CNS), including the spinal cord. About 60% will be in the posterior cranial fossa (particularly the cerebellum ).
K562 cells were the first human immortalised myelogenous leukemia cell line to be established. K562 cells are of the erythroleukemia type, and the cell line is derived from a 53-year-old female chronic myelogenous leukemia patient in blast crisis. [ 1][ 2] The cells are non-adherent and rounded, are positive for the bcr:abl fusion gene, and ...
U937 (cell line) U-937 cells are a pro-monocytic model cell line used in biomedical research. [ 1] They were isolated from the histiocytic lymphoma of a 37-year-old male patient in 1974. [ 2] Due to the relative uniformity of expanded cultures and lower maintenance requirements these cells have been since used as an important tool for studying ...
Hard lump with a scaly top or ulceration. [ 1] Cutaneous squamous-cell carcinoma ( cSCC ), also known as squamous-cell carcinoma of the skin or squamous-cell skin cancer, is one of the three principal types of skin cancer, alongside basal-cell carcinoma and melanoma. [ 10] cSCC typically presents as a hard lump with a scaly surface, though it ...
A20 cells. A20 cells, also called ATCC TIB-208, is a cell line originally derived from B-cell lymphoma in an old BALB/c mouse. [1] AT20 cells are BALB/c lymphoma cells derived from spontaneous reticulum cell neoplasm. [2] ATCC TIB-208 cells originated from B-cell lymphoma in the reticulum cell sarcoma of an elderly BALB/c mouse. [3]