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Characteristics. HCT116 cells have a mutation in codon 13 of the KRAS proto-oncogene, and are suitable transfection targets for gene therapy research. [ 2] The cells have an epithelial morphology and can metastasize in xenograft models. [ 1] When transducted with viral vectors carrying the p53 gene, HCT116 cells remain arrested in the G1 phase ...
Formally known as U-87 MG (abbreviation for Uppsala 87 Malignant Glioma), the U87 cell line has an epithelial morphology and was obtained from a 44-year-old female patient in 1966 at Uppsala University. The cell line was thought to be deposited at the Memorial Sloan Kettering Cancer Center in 1973, after which the ATCC obtained it in 1982. [ 2]
Originally the cell line was named MCF-7/ADR-RES; it was renamed together with the change in classification. Two brain cancer cell lines, SNB-19 and U251, were discovered to come from the same person. This makes a mixup likely. A 61st cell line, MDA-N, has been confirmed to being derived from the misclassified MDA-MB-435 cell line.
K562 cells were the first human immortalised myelogenous leukemia cell line to be established. K562 cells are of the erythroleukemia type, and the cell line is derived from a 53-year-old female chronic myelogenous leukemia patient in blast crisis. [ 1][ 2] The cells are non-adherent and rounded, are positive for the bcr:abl fusion gene, and ...
The International Classification of Diseases for Oncology (ICD-O) is a domain-specific extension of the International Statistical Classification of Diseases and Related Health Problems for tumor diseases. This classification is widely used by cancer registries. It is currently in its third revision (ICD-O-3). ICD-10 includes a list of ...
MCF-7. MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old White woman. [ 1] MCF-7 is the acronym of Michigan Cancer Foundation-7, referring to the institute in Detroit where the cell line was established in 1973 by Herbert Soule and co-workers. [ 2] The Michigan Cancer Foundation is now known as the Barbara Ann Karmanos ...
U937 (cell line) U-937 cells are a pro-monocytic model cell line used in biomedical research. [ 1] They were isolated from the histiocytic lymphoma of a 37-year-old male patient in 1974. [ 2] Due to the relative uniformity of expanded cultures and lower maintenance requirements these cells have been since used as an important tool for studying ...
Lymph node with mantle cell lymphoma (low-power view, H&E) According to the World Health Organization (WHO), lymphoma classification should reflect in which lymphocyte population the neoplasm arises. [23] Thus, neoplasms that arise from precursor lymphoid cells are distinguished from those that arise from mature lymphoid cells. [23]